Prunus laurocerasus L. extracts prevent paracetamol-induced nephrotoxicity by regulating antioxidant status: an experimental animal model
نویسندگان
چکیده
Paracetamol is a popular analgesic drug and its overdose may cause toxicity in the kidney. Prunus laurocerasus L. (PL) an important folklore medicinal plant that has antioxidant properties. This study explores effects of PL fruit water ethanol-water extracts administrations on oxidative stress paracetamol-induced nephrotoxicity. For this purpose, 30 rats were divided into 5 groups: control, negative control (2 g/kg paracetamol), extract (400 mg/kg PLW+ 2 PLEW+ paracetamol) positive (150 NAC+ paracetamol). 24 hours after paracetamol induction, animals sacrificed parameters analyzed spectrophotometrically kidney tissue. PLW PLEW decreased MDA NOx levels increased SOD CAT activities can restore changes caused by paracetamol.
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ژورنال
عنوان ژورنال: Hitite journal of science and engineering
سال: 2022
ISSN: ['2148-4171', '2149-2123']
DOI: https://doi.org/10.17350/hjse19030000280